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Fabrication of bioactive 3D printed porous titanium implants with Sr ions-incorporated zeolite coatings for bone ingrowth

Abstract

Functionalization of porous titanium alloy implants with bioactive coatings to improve bone regeneration performance is hotly pursued in recent decade. Here we demonstrate a facile strategy to the design of bioactive 3D printed porous titanium implants with strontium (Sr) ions incorporated zeolite coatings (SZCs). The SZCs can be uniformly fabricated on the 3D porous scaffolds by an in situ hydrothermal crystal growth method to improve their osteogenesis and osteointegration capacity. In vitro experiments of SZCs on TC4 disk show that Sr ions can slowly release to the simulated body fluid by means of ion-exchange, thus can drastically improve apatite forming ability, biocompatibility, corrosion resistance, and alkaline phosphatase (ALP) activity. In vivo evaluation on a rabbit model with the 3D printed titanium implants shows that the SZCs could significantly induce new bone formation both in and around the porous implants within four weeks. This work may open up a new method for the development of bioactive customized porous implants by functionalization with zeolite coatings in orthopedic applications.

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Publication details

The article was received on 03 Feb 2018, accepted on 11 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00328A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Fabrication of bioactive 3D printed porous titanium implants with Sr ions-incorporated zeolite coatings for bone ingrowth

    S. Wang, R. Li, D. Li, Z. Zhang, G. Liu, H. Liang, Y. Qin, J. Yu and Y. Li, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00328A

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