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Issue 18, 2018
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A novel mitochondria-targeted rhodamine analogue for the detection of viscosity changes in living cells, zebra fish and living mice

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Abstract

Monitoring the intracellular viscosity changes is crucial for better understanding diffusion-controlled cellular processes. Herein, we synthesized a novel phenyl-substituted imidazole-fused rhodamine analogue RV-1 with a long absorption wavelength at 573 nm and a large Stokes shift of about 82 nm for monitoring the changes in cellular viscosity. The new probe RV-1 showed a very strong fluorescence emission at around 655 nm, with a 48.5-fold enhancement of fluorescence intensity from methanol to 99% glycerol. Significantly, the innovative probe RV-1 was successfully applied for the detection of viscosity changes not only in living cells, but also in zebra fish and living mice.

Graphical abstract: A novel mitochondria-targeted rhodamine analogue for the detection of viscosity changes in living cells, zebra fish and living mice

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Publication details

The article was received on 01 Feb 2018, accepted on 02 Apr 2018 and first published on 10 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00298C
Citation: J. Mater. Chem. B, 2018,6, 2894-2900
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    A novel mitochondria-targeted rhodamine analogue for the detection of viscosity changes in living cells, zebra fish and living mice

    R. Guo, J. Yin, Y. Ma, Q. Wang and W. Lin, J. Mater. Chem. B, 2018, 6, 2894
    DOI: 10.1039/C8TB00298C

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