Jump to main content
Jump to site search


A novel mitochondria-targeted rhodamine analogue for detection of viscosity changes in living cells, zebra fishes and living mice

Abstract

Monitoring the intracellular viscosity changes is crucial to better understand the diffusion-controlled cellular processes. Herein,we synthesized a novel phenyl-substituted imidazole fused rhodamine analogue RV-1 with long absorption at 573 nm and a large Stokes shift about 82 nm for monitoring the change of cellular viscosity The new probe RV-1 showed very strong fluorescence emission at around 655 nm, with a 48.5-fold enhancement of fluorescence intensity from methanol to 99% glycerol. Significantly, the innovative probe RV-1 was successfully applied for detection of the viscosity change not only in living cells,but also in zebra fishes and living mice.

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Feb 2018, accepted on 02 Apr 2018 and first published on 10 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00298C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    A novel mitochondria-targeted rhodamine analogue for detection of viscosity changes in living cells, zebra fishes and living mice

    R. Guo, J. Yin, Y. Ma, Q. A. wang and W. Lin, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00298C

Search articles by author

Spotlight

Advertisements