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Highly Photoluminescent Carbon Dots Derived from Linseed and Their Applications in Cellular Imaging and Sensing

Abstract

Carbon dots (CDs) synthesized from natural organics precursors (such as glucose, citric acid, glycerol, and chitosan, et al) have attracted great interests since the natural organic precursors provide abundant carbon sources, varieties of heteroatom doping (such as N, S, and P) and good biocompatibility. However, previous approaches utilized organic solvents during the synthesis procedures, which limited their widespread development in biomedical applications. Here, facile synthesis of a new kind of bright CDs has been reported through an eco-friendly method that employs the linseed as a natural precursor. The obtained CDs possessed a high quantum yield of 14.2 %, excellent solubility and photostability as well as excitation-dependent photoluminescence (PL). In addition, the as-prepared CDs exhibited great potential in cell imaging, thanks to negligible cytotoxicity, as well as excellent biocompatibility and great resistance to photobleaching. Subsequently, the as-prepared CDs were also applied in the fabrication of biosensor for sensitive detection of butyrylcholinesterase (BChE) based on the fluorescence quenching mechanism, which can be used as an indicator for detecting pesticides and nerve gases. By monitoring the change in the fluorescent intensity of the CDs, the activity of BChE was sensitively analyzed. The limit of detection (LOD) of BChE was 0.035 mU mL−1. The prepared CDs have potential applications in both biosensors and bio-imaging.

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Publication details

The article was received on 14 Jan 2018, accepted on 01 Apr 2018 and first published on 04 Apr 2018


Article type: Paper
DOI: 10.1039/C8TB00116B
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Highly Photoluminescent Carbon Dots Derived from Linseed and Their Applications in Cellular Imaging and Sensing

    Y. Song, X. Yan, Z. Li, L. Qu, C. Zhu, R. Ye, S. Li, D. Du and Y. Lin, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00116B

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