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A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

Abstract

In this work, cellular/intranuclear dual-targeting nanoplatform was designed for tumor photothermal therapy (PTT). As a photo-to-heat nanoheater, gold nanostar (GNS) was decorated with the nuclear localization sequence (NLS) to form GNS-NLS which processed the ability of nuclear-targeting. After that, hyaluronic acid (HA) was coated on the surface of GNS-NLS (GNS-NLS@HA) via electrostatic interaction for tumor cellular recognition and targeting. It was found that by harnessing the recognition of CD44 receptor from HA, GNS-NLS@HA had the ability to target tumor cells accurately, and further be internalized into cells with the stellate shape efficaciously. Subsequently, tumor intracellular hyaluronidase (HAase) from endsome led to the degradation of HA to expose nuclear-targeting nanoheater GNS-NLS, and GNS-NLS realized enhancing PTT efficiency through subcellular nuclear location by a dual-stage near infrared (NIR) light irradiation strategy. The first stage light irradiation was short-time to enhance the subcellular location of the nanoplatform to nuclei, and the second stage light irradiation was long-time to achieve admirable photothermal transduction as well as destruction of nuclei. This cellular/intranuclear dual-targeting nanoplatform GNS-NLS@HA displayed prominent tumor suppression efficiency both in vitro and in vivo, and inhibited tumor metastasis effectively.

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Publication details

The article was received on 10 Jan 2018, accepted on 13 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C8TB00087E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A cellular/intranuclear dual-targeting nanoplatform based on gold nanostar for accurate tumor photothermal therapy

    S. Chen, J. Fan, W. Qiu, F. Liu, G. Yan, X. Zeng and X. Zhang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB00087E

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