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Issue 16, 2018
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Composites based on heparin and MIL-101(Fe): the drug releasing depot for anticoagulant therapy and advanced medical nanofabrication

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Abstract

We describe the synthesis and properties of a new composite material based on heparin and MIL-101(Fe) metal–organic framework. The intrinsic instability of MIL-101(Fe) towards hydrolysis enables binding of heparin molecules to the framework structure as is evidenced by DFT calculations and adsorption experiments. The de novo formed heparin–MOF composites showed good biocompatibility in in vitro and demonstrated pronounced anticoagulant activity. The specific interaction between the bioactive molecule and the carrier is critical for the selective degradation of the complex in the body fluids and for the enhanced activity. Hep_MIL-101(Fe) composite could serve as a drug-releasing depot for nanofabrication and to introduce anticoagulant activity to medical devices and biocoatings. Addition of Hep_MIL-101(Fe) to a sol–gel derived thrombolytic matrix allowed the combination of anticoagulant and thrombolytic activities in a single hybrid nanomaterial that could be applied as a bioactive nanocoating for PTFE vein implants.

Graphical abstract: Composites based on heparin and MIL-101(Fe): the drug releasing depot for anticoagulant therapy and advanced medical nanofabrication

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Publication details

The article was received on 09 Jan 2018, accepted on 21 Feb 2018 and first published on 22 Feb 2018


Article type: Paper
DOI: 10.1039/C8TB00072G
Citation: J. Mater. Chem. B, 2018,6, 2450-2459
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    Composites based on heparin and MIL-101(Fe): the drug releasing depot for anticoagulant therapy and advanced medical nanofabrication

    V. V. Vinogradov, A. S. Drozdov, L. R. Mingabudinova, E. M. Shabanova, N. O. Kolchina, E. I. Anastasova, A. A. Markova, A. A. Shtil, V. A. Milichko, G. L. Starova, R. L. M. Precker, A. V. Vinogradov, E. Hey-Hawkins and E. A. Pidko, J. Mater. Chem. B, 2018, 6, 2450
    DOI: 10.1039/C8TB00072G

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