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Issue 15, 2018
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Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

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Abstract

Improving tumor oxygenation and concentrating X-ray radiation energy inside the tumor have received considerable attention in cancer radiotherapy. Herein, core–shell tantalum oxide@manganese dioxide (TaOx@MnO2) nanostructures are prepared as an efficient radiosensitizer for enhancing radiotherapy (RT). In these nanostructures, the TaOx core serves as a RT sensitizer that efficiently concentrates X-ray radiation energy inside the tumor, while the MnO2 shell may trigger the decomposition of endogenous H2O2 in the tumor microenvironment (TME) to generate oxygen and overcome hypoxia-associated radiation resistance. In vitro and in vivo experiments demonstrated that the synthesized TaOx@MnO2-PEG nanostructures could accomplish an excellent synergistic radiotherapy sensitization effect. Furthermore, TaOx@MnO2-PEG nanoparticles could also serve as promising agents for MR/CT dual-modal imaging. In brief, our study highlights a new type of multifunctional radiosensitizer agent to enhance radiotherapy treatment by means of simultaneously concentrating radiation energy inside tumors and overcoming tumor hypoxia, promising for applications in tumor radiotherapy.

Graphical abstract: Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

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Publication details

The article was received on 09 Jan 2018, accepted on 07 Mar 2018 and first published on 07 Mar 2018


Article type: Paper
DOI: 10.1039/C8TB00070K
Citation: J. Mater. Chem. B, 2018,6, 2250-2257
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    Core–shell TaOx@MnO2 nanoparticles as a nano-radiosensitizer for effective cancer radiotherapy

    F. Gong, J. Chen, X. Han, J. Zhao, M. Wang, L. Feng, Y. Li, Z. Liu and L. Cheng, J. Mater. Chem. B, 2018, 6, 2250
    DOI: 10.1039/C8TB00070K

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