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Synthesis of hydrogels-bearing phenylboronic acid moieties and their applications in glucose sensing and insulin delivery

Abstract

In past few years, phenylboronic acids (PBAs) have caught researcher’s attention due to their unique responsiveness towards diol-containing molecules such as glucose. This property allows hydrogels-bearing PBA potentially to serve as an alternative for the glucose sensing and insulin delivery systems. This review gives an outlook on the binding mechanism of PBA moieties with diols and the approaches to increase their binding selectivity and response for glucose molecule. The preparation methods and strategies of hydrogels-bearing PBA moieties along with their properties are discussed. In the last section, their applications in glucose sensing and insulin regulatory systems are described.

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Publication details

The article was received on 27 Dec 2017, accepted on 14 May 2018 and first published on 15 May 2018


Article type: Review Article
DOI: 10.1039/C7TB03332J
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Synthesis of hydrogels-bearing phenylboronic acid moieties and their applications in glucose sensing and insulin delivery

    T. Shaarani, J. H. Yu, L. Wang, Z. ul Abdin, R. S. Ullah, M. Haroon, R. U. Khan, S. Fahad, A. Khan, A. Nazir, M. Usman and K. Naveed, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03332J

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