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Recent advances in biomolecule immobilization based on self-assembly: organic-inorganic hybrid nanoflowers and metal-organic frameworks as novel substrates

Abstract

In the last few years, the immobilization of biomolecules on hybrid nanoflowers and metal-organic frameworks (MOFs) via self-assembly synthesis have received much attention due to their simple synthesis, high efficiency, and bright prospect of enhancing stability, activity and even selectivity of biomolecules compared to conventional immobilization methods. In the synthesis of organic-inorganic hybrid nanoflowers, biomolecules used as the organic components are simply mixed with metal ions which act as the inorganic components to form the flower-like nanocomposites. While in the self-assembly process of encapsulating biomolecules in MOFs (biomolecule@MOF composites), biomolecules just need to be added to the precursor mixtures of MOFs, in which the biomolecules are therefore embedded in MOF crystals with small pores . In this review, we focus on the recent advances of these composites, especially in the synthesis strategies, mechanism and applications in biosensor, biomedicine, pollutant disposal, and Industrial biocatalysis, and future perspectives are discussed as well.

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Publication details

The article was received on 24 Dec 2017, accepted on 02 Feb 2018 and first published on 02 Feb 2018


Article type: Review Article
DOI: 10.1039/C7TB03310A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Recent advances in biomolecule immobilization based on self-assembly: organic-inorganic hybrid nanoflowers and metal-organic frameworks as novel substrates

    Z. A. Lin, Z. X. Lei, C. L. Gao, L. Chen, Y. He and W. D. Ma, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03310A

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