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A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

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Abstract

A new hemicyanine-based fibroblast activation protein-targeted near-infrared fluorescent probe is designed and it shows high selectivity and sensitivity to cancer cell detection, and in vitro and in vivo imaging. This probe is successfully applied in fluorescence detection of living cells (with a detection limit of 1500 cells per mL). It is believed that many new functions or distributions of FAP could be discovered by this new probe later.

Graphical abstract: A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

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Publication details

The article was received on 23 Dec 2017, accepted on 26 Jan 2018 and first published on 26 Jan 2018


Article type: Communication
DOI: 10.1039/C7TB03303F
Citation: J. Mater. Chem. B, 2018, Advance Article
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    A novel fibroblast activation protein-targeted near-infrared fluorescent off–on probe for cancer cell detection, in vitro and in vivo imaging

    J. Xing, Q. Gong, R. Zou, Z. Li, Y. Xia, Z. Yu, Y. Ye, L. Xiang and A. Wu, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB03303F

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