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Micro- and Nano-structured 3D Printed Titanium Implants with Hydroxyapatite Coating for Improved Osseointegration

Abstract

With the increasing demand for low-cost and more efficient dental implants, there is an urgent need for developing new manufacturing approaches and implants with better osseointegration performances. 3D printing technology can provides enormous opportunities for rapid fabrication of a new generation of patient-tailored dental implants with significantly reduced costs. This study presents the demonstration of a unique model of titanium implants based on 3D printing technology with improved osseointegration properties. The titanium alloy (Ti6Al4V) implants with micro-structured surface are fabricated with a selective laser-melting process followed by further nano-structuring with electrochemical anodization to form titania nanotubes (TNT) and subsequent bioactivation by hydroxyapatite (HA) coating. The osseointegration properties of the fabricated implants were examined using human primary osteoblasts. The results showed significantly increased protein adsorption, cell adhesion and cell spreading. The expression of the late osteoblast/osteocyte genes GJA1 and PHEX was also enhanced, indicating a cell maturation effect and promotion of mineralization on the surfaces. These results suggest that 3D printing technology combined with electrochemical nano-structuring and HA modification is a promising approach for fabrication of Ti implants with improved osseointegration and provides potential alternatives to conventional dental implants.

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Publication details

The article was received on 17 Dec 2017, accepted on 12 Apr 2018 and first published on 13 Apr 2018


Article type: Paper
DOI: 10.1039/C7TB03251J
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Micro- and Nano-structured 3D Printed Titanium Implants with Hydroxyapatite Coating for Improved Osseointegration

    Q. Jie, D. Yang, S. Maher, L. lima-marques, Y. Zhou, Y. Chen, G. J. Atkins and D. Losic, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03251J

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