Jump to main content
Jump to site search

Issue 9, 2018
Previous Article Next Article

Nanoinitiator for enzymatic anaerobic polymerization and graft enhancement of gelatin–PAAM hydrogel

Author affiliations

Abstract

As an emerging method for mildly molding polymer hydrogel bioscaffolds, the enzymatically polymerized system is mainly based on the screening of various oxidoreductases to produce radicals, but the design of multifunctional nanoinitiators to facilitate hydrogel performance remains challenging. Here, we utilize N-hydroxyimide-modified silica nanoparticles as nanoinitiators to simultaneously trigger glucose oxidase anaerobic polymerization and nanoparticle-grafting enhancement of the gelatin–polyacrylamide (PAAM) hydrogel. The enzyme–nanoinitiator system produced nitrogen radicals, which were further converted into carbon radicals via GOx-catalyzed glucose reduction, as confirmed by electron paramagnetic resonance (EPR) analysis. Our stretchable hydrogel has a 12-fold increased fracture energy relative to traditional hydrogel due to grafting enhancement by the nanoinitiator. The temperature-dependent physical crosslinking of gelatin endowed our hydrogel facile printing ability. Cytotoxicity assay and 3D cell culture demonstrated the low toxicity of our hydrogel. As the first example of the use of nanoinitiators for enzymatic polymerization, this work provides a biocompatible platform to prepare or print hydrogel bioscaffolds with the required mechanical strength.

Graphical abstract: Nanoinitiator for enzymatic anaerobic polymerization and graft enhancement of gelatin–PAAM hydrogel

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Dec 2017, accepted on 08 Feb 2018 and first published on 12 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB03244G
Citation: J. Mater. Chem. B, 2018,6, 1402-1409
  •   Request permissions

    Nanoinitiator for enzymatic anaerobic polymerization and graft enhancement of gelatin–PAAM hydrogel

    Q. Zhang, Y. Lv, M. Liu, X. Wang, Y. Mi and Q. Wang, J. Mater. Chem. B, 2018, 6, 1402
    DOI: 10.1039/C7TB03244G

Search articles by author

Spotlight

Advertisements