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An injectable hydrogel scaffold loaded with MSCs for potential application of treating traumatic brain injury

Abstract

In the past few decades, stem cell replacement therapy has presented its potential application in the treatment of nervous system damage diseases, such as traumatic brain injury (TBI). However, the insufficient number of transplanted stem cells and low survival rate that caused by series of negative conditions limit the therapeutic effect. In this contribution, we developed an injectable hydrogel composed of sodium alginate (SA) and hyaluronic acid (HA), as the tissue scaffold to create better microenvironment for the stem cells after implantation. The HA/SA hydrogel showed the gelation time of exceeded 6 min, satisfying requirements of the injecting performance, while both the high ratios of water content and slower degradation speed affirmed the HA/SA hydrogel as a preferable stem cell scaffold. As a tissue engineering scaffold, the HA/SA hydrogel exhibited appropriately porous structures for the stem cell loading and good rheological behavior which contributed to the stem cell differentiation. The in vitro culture experiment proved the better ability of the HA/SA scaffold on higher hUC-MSCs viability ratio and proliferation. The further in vivo tests indicated that the HA/SA scaffold not only protected the injected hUC-MSCs to maintain a higher survival ratio, but also contributed to the regeneration of endogenous nerve cells. In summary, the research of this injectable HA/SA hydrogel may contribute potential application for stem cells tissue engineering and support the physiological function recovery of TBI patients.

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Publication details

The article was received on 13 Dec 2017, accepted on 09 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C7TB03213G
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    An injectable hydrogel scaffold loaded with MSCs for potential application of treating traumatic brain injury

    K. Zhang, Z. Shi, F. Guan, J. Zhou, Q. Xing, S. Ma, Q. Li, Y. Zhang, M. Yao, X. Wang, Q. Li and J. Li, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03213G

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