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Biologically-Inspired, Catechol-Coordinated, Hierarchical Organization of Raspberry-like Calcium Phosphate Nanospheres with High Specific Surface Area

Abstract

The elaborate design of calcium phosphates (CaP) with hierarchical structure for biomedical applications is severely restricted by their instinctive pertinacious irregular agglomeration. The development of mesoporous CaP with large pores inside is far from satisfactory. In this study, variable catechol is selected as the modifier to intervene the precipitation of CaP. In contrast to the pure CaP of smooth irregular aggregates with the average size of 110 nm, the catechol-intervened CaP (CaP/Cat) samples are raspberry-like nano spherical assemblies of ca. 25 nm nanoparticles. The obtained spheres possess mesoporous structure, interior large pores and high specific surface area, which endow them with high proteins adsorption capacity and high efficacy of DNA delivery. Catechol is subjected to oxidative polymerization while the CaP precipitates occur. This simultaneous reaction is supposed to impose a crucial influence on directing the assembling of CaP/Cat nanospheres. The flexible catechol is shown to be a novel and promising modifier for manufacturing CaP with tunable structure and properties for various applications.

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Publication details

The article was received on 07 Dec 2017, accepted on 11 May 2018 and first published on 14 May 2018


Article type: Paper
DOI: 10.1039/C7TB03156D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Biologically-Inspired, Catechol-Coordinated, Hierarchical Organization of Raspberry-like Calcium Phosphate Nanospheres with High Specific Surface Area

    X. Ma, Z. Sun, W. Su, Z. Yi, X. Cui, B. Guo and X. Li, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03156D

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