Jump to main content
Jump to site search


Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities

Abstract

An elevated reactive oxygen species (ROS) leads to cellular oxidative stress, which has long been associated with diseases, such as cancer. Thus, the understanding and appropriate manipulation of cellular oxidative stress are needed for disease treatment. It has been reported that nanoparticles induce oxidative stress in human cells through different pathways. However, how nanoparticles’ physicochemical properties perturb cellular oxidative stress remains unclear. In this paper, we explored the effects of positive/negative charge density and hydrophobicity of gold nanoparticles (GNPs) on the induction of oxidative stress and related mechanisms. In multiple human cell lines, we found that only positive charge density and hydrophobicity of nanoparticles were correlated with the induction of cellular oxidative stress. Hydrophobic nanoparticles generated oxidative stress mainly through NADPH oxidase activation while positively charged nanoparticles through perturbations of mitochondria and modulation of intracellular Ca2+ concentration. Furthermore, nanoparticle-induced oxidative stress sensitized paclitaxel-induced cancer cell killing by 200%. These findings provided unequivocal structural parameters for design of future nanomedicine and biocompatible nanocarriers.

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Dec 2017, accepted on 05 Feb 2018 and first published on 06 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB03153J
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
  •   Request permissions

    Induction of oxidative stress and sensitization of cancer cells to paclitaxel by gold nanoparticles with different charge densities and hydrophobicities

    H. Sun, Y. Liu, X. Bai, X. Zhou, H. Zhou, S. Liu and B. Yan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03153J

Search articles by author

Spotlight

Advertisements