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Oral Administration of Highly Bright Cr3+ Doped ZnGa2O4 Nanocrystals for in vivo Targeted Imaging of Orthotopic Breast Cancer

Abstract

Near-infrared (NIR) long lasting persistent luminescence nanoparticles (PLNPs) have attracted considerable attention in the area of in vivo bioimaging, due to their background-free luminescence characteristics and deep tissue penetration. The low fluorescence quantum yield and short afterglow of currently available PLNPs limit their applications, however. Here, water-soluble Cr3+-doped ZnGa2O4 PLNPs with the highest quantum yield (η = 20%) ever reported, bright NIR emission, and excellent colloidal stability were successfully prepared by a one-step hydrothermal method. The afterglow of the resultant nanocrystals lasted for more than 5 days and could be repeatedly reactivated by the light (λ = 657 nm) of a portable light emitting diode lamp after decay. These nanocrystals were functionalized with α,ω-dicarboxyl-terminated poly(ethylene glycol) and poly(acrylic acid) to improve their stability and biocompatibility, so that they could be conjugated with c(RGDyK) peptide and labeled with 99mTc for targeted imaging of orthotopic breast cancer by afterglow luminescence imaging and single-photon emission computed tomography imaging for the first time. Our NIR-PLNPs probes can effectively avoid tissue auto-fluorescence and the light scattering caused by continuous excitation during diagnosis of cancer.

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Publication details

The article was received on 06 Dec 2017, accepted on 05 Feb 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB03148C
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Oral Administration of Highly Bright Cr3+ Doped ZnGa2O4 Nanocrystals for in vivo Targeted Imaging of Orthotopic Breast Cancer

    Z. Li, H. Liu, F. Ren, H. Zhang, Y. Han, H. Qin, J. Zeng, Y. Wang, Q. Sun and M. Gao, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03148C

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