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Strategies to Design Antimicrobial Contact Lenses and Contact Lens Cases


Contact lens wear is a primary risk factor for developing ocular complications, such as contact lens acute red eye (CLARE), contact lens-induced peripheral ulcer (CLPU) and microbial keratitis (MK). Infections occur due to microbial contamination of contact lenses, lens cases and lens care solution, which are exacerbated by extended lens wear and unsanitary lens care practices. The development of microbial biofilms inside lens cases is an additional complication, as the developed biofilms are resistant to conventional lens cleaning solutions. Ocular infections, particularly in case of MK, can lead to visual impairment or even blindness, so there is a pressing need for the development of antimicrobial contact lenses and cases. Additionally, with the increasing use of bandage contact lenses and contact lenses as drug depots and with the development of smart contact lenses, the contact lens hygiene becomes a therapeutically important issue. In this review, we attempt to compile and summarize various chemical strategies for developing antimicrobial contact lenses and lens cases by using silver, free-radical producing agents, antimicrobial peptides or by employing passive surface modification approaches. We also evaluated the advantages and disadvantages of each system and tried to provide inputs over the future directions. Finally, we summarize the developing technologies of the therapeutic contact lenses to illuminate the future of contact lens applications.

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Publication details

The article was received on 05 Dec 2017, accepted on 01 Mar 2018 and first published on 01 Mar 2018

Article type: Review Article
DOI: 10.1039/C7TB03136J
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Strategies to Design Antimicrobial Contact Lenses and Contact Lens Cases

    A. Xiao, C. Dhand, C. M. Leung, R. W. Beuerman, S. Ramakrishna and R. Lakshminarayanan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03136J

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