Jump to main content
Jump to site search

Issue 10, 2018
Previous Article Next Article

Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast

Author affiliations

Abstract

Magnetic iron oxide nanoparticles have been used for various applications such as in the treatment of iron deficiency, as theranostic agents, and as drug carriers. The effective delivery of magnetic iron oxide nanoparticles into the lesion and iron quantification are vital for in vivo theranostic application. To determine the feasibility of using T1 contrast to non-invasively quantify and monitor the IONPs in vivo, monodispersed Gd-doped iron oxide nanoparticles (GdIONPs) with 4 nm core size were fabricated and were used as T1-weighted contrast agents to quantify iron contents based on MRI longitudinal relaxation times (T1). Signal enhancement in positive T1 contrast caused by GdIONPs was observed in this work. The in vivo T1 relaxivity of GdIONPs in a tumor matched well with both in vitro T1 relaxivity and ICP-MS results, demonstrating that the concentration of iron at the tumor site can be directly read from real-time in vivo MRI T1 relaxivity. Hence, by using this strategy, the Fe content in the lesion can be accurately monitored based on MRI longitudinal relaxation times, and this may shed light on effective magnetic hyperthermia cancer therapy in future.

Graphical abstract: Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Dec 2017, accepted on 26 Jan 2018 and first published on 26 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB03129G
Citation: J. Mater. Chem. B, 2018,6, 1470-1478
  •   Request permissions

    Magnetic resonance imaging quantification and biodistribution of magnetic nanoparticles using T1-enhanced contrast

    Y. B. Lv, P. Chandrasekharan, Y. Li, X. L. Liu, J. P. Avila, Y. Yang, K. H. Chuang, X. Liang and J. Ding, J. Mater. Chem. B, 2018, 6, 1470
    DOI: 10.1039/C7TB03129G

Search articles by author

Spotlight

Advertisements