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Near infrared photothermal-responsive poly(vinyl alcohol)/black phosphorus composite hydrogels with excellent on-demand drug release capacity

Abstract

Owing to the excellent tissue-penetration ability, near-infrared (NIR) photothermal-responsive intelligent materials gradually show their unexampled advantages in biomedical applications. However, majorities of the previously reported NIR-absorbing agents are metal- and carbon-based nanoparticles, and both of which possess low photothermal conversion efficiency and poor biocompatibility. Herein, polydopamine modified black phosphorus (pBP) nanosheets-containing poly(vinyl alcohol) (PVA) composite hydrogels are facilely fabricated via a freezing/thawing approach. Taking advantages of the high photothermal conversion efficiency of pBP, the prepared composite hydrogels exhibit a fascinating on-demand NIR-responsive drug release behavior. In vitro cell culture study demonstrates that these composite hydrogels present good biocompatibility and cellular interaction. Moreover, since the incorporated pBP nanosheets can form strong hydrogen bonding interaction within the PVA matrix, the composite hydrogels also show an enhanced mechanical property. We believe that the robust mechanical properties, excellent biocompatibility, accompanied with the highly controllable NIR-responsive drug release performance of the obtained composite hydrogel augur well for its diverse future applications in biomedical field.

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Publication details

The article was received on 29 Nov 2017, accepted on 31 Jan 2018 and first published on 31 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB03090H
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Near infrared photothermal-responsive poly(vinyl alcohol)/black phosphorus composite hydrogels with excellent on-demand drug release capacity

    G. Yang, X. Wan, Z. Gu, X. Zeng and J. Tang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03090H

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