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Construction of High Surface Potential Polypyrrole Nanorods with Enhanced Antibacterial Properties

Abstract

Conductive polymers (CPs) are frequently used as neural and osteogenic implants for signal recording and electrical stimulation due to their electroactive and good biocompatibility. However, these implants often fail due to bacterial infection. In this research, a novel nano-functionalized polypyrrole (PPy) with high surface potential was electrochemically developed to improve the antibacterial properties of CPs. Sulfosalicylic acid (SSA)—a biomolecule with abundant negatively charged functional groups—was introduced to not only successfully assist in the electrical assembly of the Py micelle into bacterial extracellular matrix mimetic nanostructure, but also to modulate the surface electrical property of PPy. Scanning Kelvin probe microscopy (SKPM) results confirm the increased positive charges on the SSA-assisted PPy (PPy/SSA nanorod and irregular PPy/SSA film) relative to the irregular PPy/Cl film. The plate colony-counting experiments confirm that SSA-assisted PPy has excellent antibacterial properties relative to irregular PPy/Cl film. The higher antibacterial rate for PPy/SSA nanorod suggests a synergistic effect via the nanorod structure and the high surface potential induced by dopants. Cytotoxicity testing demonstrates that the PPy/SSA samples were nontoxic to the cells. Our work is an effective way to develop antibacterial CPs.

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Publication details

The article was received on 28 Nov 2017, accepted on 02 Apr 2018 and first published on 03 Apr 2018


Article type: Paper
DOI: 10.1039/C7TB03085A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Construction of High Surface Potential Polypyrrole Nanorods with Enhanced Antibacterial Properties

    W. Zhou, L. Lu, D. Chen, Z. Wang, J. Zhai, R. Wang, G. Tan, J. Mao, P. Yu and C. Ning, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB03085A

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