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Issue 9, 2018
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Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor

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Abstract

The development of an ultrasensitive nanoprobe is regarded as one of the most promising strategies for the precise diagnosis of tumors. Herein, tanespimycin (17-AAG)-modified polyethylenimine-based gold nanoparticles (AuNPs) co-labeled with a gadolinium (Gd) nanoprobe are constructed for targeted dual-mode computed tomography (CT)/magnetic resonance (MR) imaging. The specific binding of tanespimycin to the N-terminal of heat shock protein 90 (HSP90) endows the modified nanoprobes (NPs) with the ability to up-regulate HSP90 tumor cells and to display excellent X-ray attenuation intensity and T1 MR imaging performance in an orthotopic hepatocellular carcinoma tumor model. Such an ultrasensitive nanoprobe holds enormous promise for highly efficient tumor diagnosis and dual-mode CT/T1 positive MR imaging. This study develops a novel strategy to prepare a multifunctional nanoprobe via polyethylenimine nanotechnology. Using this strategy, various dual-mode or multimode nanoprobes for diagnosing different cancers may be designed.

Graphical abstract: Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor

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Publication details

The article was received on 27 Nov 2017, accepted on 27 Jan 2018 and first published on 05 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB03076B
Citation: J. Mater. Chem. B, 2018,6, 1342-1350
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    Heat shock protein-guided dual-mode CT/MR imaging of orthotopic hepatocellular carcinoma tumor

    R. Wang, Y. Luo, X. Li, A. Ji, R. Guo, X. Shi and X. Wang, J. Mater. Chem. B, 2018, 6, 1342
    DOI: 10.1039/C7TB03076B

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