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Issue 18, 2018
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Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications

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Abstract

The desired mechanical and biological performances of collagen that have led to its broad application as a building block in the biomedical field attributed to its intrinsic hierarchical structure from the nanoscale to macroscale, are discussed herein. Modulating the self-assembly process using regulatory factors can lead to obtaining collagenous materials with tuneable functional performance, which can then determine distinctive cellular responses. Herein, we present an overview of the corresponding characterization techniques used to detect the changes in light transmittance, architecture and mechanics during collagen fibrillogenesis. By combining regulatory parameters with characterization methods, researchers can selectively fabricate collagenous biomaterials with various functional responses.

Graphical abstract: Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications

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Publication details

The article was received on 17 Nov 2017, accepted on 29 Mar 2018 and first published on 03 Apr 2018


Article type: Review Article
DOI: 10.1039/C7TB02999C
Citation: J. Mater. Chem. B, 2018,6, 2650-2676
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    Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications

    S. Zhu, Q. Yuan, T. Yin, J. You, Z. Gu, S. Xiong and Y. Hu, J. Mater. Chem. B, 2018, 6, 2650
    DOI: 10.1039/C7TB02999C

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