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Photo-Responsive Camptothecin-based Polymeric Prodrug Coated Silver Nanoparticles for Drug Release Behavior Tracking via Nanomaterial Surface Energy Transfer (NSET) Effect

Abstract

A hybrid drug delivery system was successfully fabricated by attaching camptothecin (CPT)-based polymeric prodrug onto the surface of silver nanoparticles (AgNPs). PEG was employed as macro-RAFT agent in RAFT polymerization to synthesize branched star copolymer, to which CPT is linked through the photo-responsive o-nitrobenzyl linkage. In vitro tests indicate that the fluorescence of CPT in the polymeric prodrug is quenched by AgNPs based on the nanomaterial surface energy transfer (NSET) effect and the fluorescence recovers when CPT molecules are released from hybrid nanoparticles. Thus, the variation of fluorescence intensity is bound up with drug release behaviors, which may enable this AgNPs-based drug delivery system to trace intracellular drug release process and observe distribution of released CPT in cells.

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Publication details

The article was received on 17 Nov 2017, accepted on 05 Feb 2018 and first published on 06 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB02998E
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Photo-Responsive Camptothecin-based Polymeric Prodrug Coated Silver Nanoparticles for Drug Release Behavior Tracking via Nanomaterial Surface Energy Transfer (NSET) Effect

    J. Li, L. Qiu, X. Xu, C. Pan, C. Hong and W. Zhang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02998E

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