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A photostable AIE luminogen with near infrared emission for monitoring morphological change of plasma membrane

Abstract

The morphology of plasma membrane is dynamic and keeps changing in order to maintain its homeostasis. Abnormal in cell membrane shape could be viewed as a sign of unhealthy. A lipophilic cyanostilbene derivative (AS2CP-TPA) composed of a hydrophilic pyridinium salt and a hydrophobic triphenylamino group, was designed for staining the cell membrane and monitoring membrane morphology under different circumstances. With the effects of strong donor-acceptor interaction and aggregation-induced emission property, AS2CP-TPA emits weak emission in aqueous solution but it lights up the plasma membrance of HeLa cells with near infrared fluorescence under an excitation wavelength of 460 nm. With possessing merits of high photostability and high specificity to plasma membrane, AS2CP-TPA is capable to long-term monitor the morphological change of cell membrane in the treatments of Hg2+ and trypsin

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Publication details

The article was received on 13 Nov 2017, accepted on 09 Feb 2018 and first published on 09 Feb 2018


Article type: Paper
DOI: 10.1039/C7TB02947K
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    A photostable AIE luminogen with near infrared emission for monitoring morphological change of plasma membrane

    W. Zhang, C. Y. Y. Yu, R. T. K. Kwok, J. W. Y. Lam and B. Z. Tang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02947K

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