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PEG Conjugated BODIPY-Br2 as Macro-Photosensitizer for Efficient Imaging-guided Photodynamic Therapy

Abstract

Drug-free biocompatible nanoparticles with photosensitizers as both diagnostic and therapy agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). Here, NSH-active boron-dipyrromethene (BODIPY) derivative with bromine substituted (BODIPY-Br2, for simple as BDP-Br) photosensitizer has been synthesized, which showed high ability of generating reactive oxygen species (ROS) upon irradiation for PDT and NIR fluorescence imaging ability. Then, a simple PEGylated BDP-Br (PEG-BDP) as a kind of macro photosensitizer was prepared which has shown superior cellular uptake ability and high efficiency of imaging and curing to PDT therapy in vitro and in vivo. After administration with 4T1 orthotopic tumor model, the resultant PEG-BDP shows prolonged blood circulation and preferential tumor accumulation compared with the free BDP-Br molecules. Once accumulating in the tumor tissues, therapeutic effects of PEG-BDP could significantly suppress the primary tumor growth and has no evident side effects at a weak irradiation energy as low as 35 mW /cm2 for 20 mins. The designation of this simple structure macro photosensitizer agent provides new avenues for efficient imaging-guided cancer PDT.

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Publication details

The article was received on 10 Nov 2017, accepted on 02 Jan 2018 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02924A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    PEG Conjugated BODIPY-Br2 as Macro-Photosensitizer for Efficient Imaging-guided Photodynamic Therapy

    Z. Ruan, Y. Zhao, P. Yuan, L. Liu, Y. Wang and L. Yan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02924A

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