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PEG conjugated BODIPY-Br2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy

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Abstract

Drug-free biocompatible nanoparticles with photosensitizers as both diagnostic and therapy agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). Here, a NSH-active boron-dipyrromethene (BODIPY) derivative with a bromine substituted (BODIPY-Br2, for simplicity, BDP-Br) photosensitizer was synthesized; it showed a high ability of generating reactive oxygen species (ROS) upon irradiation for PDT and near infrared fluorescence imaging ability. Then, a simple PEGylated BDP-Br (PEG-BDP) as a kind of macro photosensitizer was prepared which showed superior cellular uptake ability, high efficiency of imaging, and curing with PDT therapy in vitro and in vivo. After administration with a 4T1 orthotopic tumor model, the resultant PEG-BDP showed prolonged blood circulation and preferential tumor accumulation compared with free BDP-Br molecules. Once accumulated in tumor tissues, therapeutic effects of PEG-BDP could significantly suppress primary tumor growth and has no evident side effects at a weak irradiation energy as low as 35 mW cm−2 for 20 minutes. The designation of this simple structure macro photosensitizer agent provides new avenues for efficient imaging-guided cancer PDT.

Graphical abstract: PEG conjugated BODIPY-Br2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy

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Publication details

The article was received on 10 Nov 2017, accepted on 02 Jan 2018 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02924A
Citation: J. Mater. Chem. B, 2018, Advance Article
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    PEG conjugated BODIPY-Br2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy

    Z. Ruan, Y. Zhao, P. Yuan, L. Liu, Y. Wang and L. Yan, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02924A

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