Silicon nanowire-based multifunctional platform for chemo-photothermal synergistic cancer therapy

Daoxia Guo; Xiaoyuan Ji; Houyu Wang; Bin Sun; Binbin Chu; Yu Shi; Yuanyuan Su; Yao He

doi:10.1039/C7TB02907A

Silicon nanowire-based multifunctional platform for chemo-photothermal synergistic cancer therapy

Daoxia Guo,^a Xiaoyuan Ji,^a Houyu Wang,^a Bin Sun,^a Binbin Chu,^a Yu Shi,^a Yuanyuan Su^a and Yao He*^a

Author affiliations

* Corresponding authors

^a Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, China
E-mail: yaohe@suda.edu.cn

Abstract

Combination therapies for cancer have been promising strategies to reverse multidrug resistance, improve treatment efficiency, and minimize side effects. Herein, a new type of multifunctional silicon nanowire (MFSiNW)-based system, i.e., iron oxide nanoparticle and gold nanoparticle decorated silicon nanowires (IONPs@AuNPs@SiNWs), is prepared through a facile synthetic strategy. The resultant nanohybrids could load therapeutic drug molecules (e.g., doxorubicin, DOX) with high drug loading capacity (2000 mg g⁻¹), and be simultaneously responsive to pH/NIR (near-infrared) light/magnetism, thus enabling high-efficacy synergistic treatment of drug-resistant cancer cells. The current work provides the pioneering demonstration of silicon nanomaterial-based combinational cancer treatment with high therapeutic efficiency.

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Publication details

The article was received on 08 Nov 2017, accepted on 10 Apr 2018 and first published on 11 Apr 2018

Article type: Paper

DOI: 10.1039/C7TB02907A

Citation: J. Mater. Chem. B, 2018,6, 3876-3883

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Silicon nanowire-based multifunctional platform for chemo-photothermal synergistic cancer therapy

D. Guo, X. Ji, H. Wang, Bin Sun, B. Chu, Y. Shi, Y. Su and Y. He, J. Mater. Chem. B, 2018, 6, 3876
DOI: 10.1039/C7TB02907A
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Journal of Materials Chemistry B

Silicon nanowire-based multifunctional platform for chemo-photothermal synergistic cancer therapy

Abstract

Supplementary files

Publication details

Silicon nanowire-based multifunctional platform for chemo-photothermal synergistic cancer therapy

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