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Silicon nanowires-based multifunctional platform for chemo-photothermal synergistic cancer therapy

Abstract

Combination therapies for cancer have been promising strategies to reverse multidrug resistance, improve treatment efficiency, and minimize side effects. Herein, a new type of multifunctional silicon nanowires (MFSiNWs)-based system, i.e., iron oxide nanoparticles and gold nanoparticles decorated silicon nanowires (IONPs@AuNPs@SiNWs), is prepared through a facile synthetic strategy. The resultant nanohybrids could load therapeutic drug molecules (e.g., doxorubicin, DOX) with high drug loading capacity (2000 mg g-1), and be simultaneously responsive to pH/NIR (near-infrared) light/magnetism, thus enabling high-efficacy synergistic treatment of drug-resistant cancer cells. This current work provides the pioneering demonstration of silicon nanomaterials-based combinational cancer treatment with high therapeutic efficiency.

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Publication details

The article was received on 08 Nov 2017, accepted on 10 Apr 2018 and first published on 11 Apr 2018


Article type: Paper
DOI: 10.1039/C7TB02907A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Silicon nanowires-based multifunctional platform for chemo-photothermal synergistic cancer therapy

    D. Guo, X. Ji, H. Wang, B. Sun, B. Chu, Y. Shi, Y. Su and Y. He, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02907A

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