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Mannan-based conjugates as a multimodal imaging platform for lymph nodes

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Abstract

We show that mannan-based conjugates possess exceptional features for multimodal imaging because of their biocompatibility, biodegradability and self-targeting properties. Two new mannan conjugates, containing a gadolinium complex and a fluorescent probe, one based only on polysaccharide and the other one comprising polysaccharide with poly(2-methyl-2-oxazoline) grafts, were prepared and simultaneously visualized in vitro and in vivo by magnetic resonance and fluorescence imaging. The synthesis of these mannan-based complexes was based on alkylation with allyl bromide or grafting with poly(2-methyl-2-oxazoline) chains, followed by a thiol–ene click reaction with cysteamine to introduce primary amino groups into their structure. Finally, the obtained conjugates were functionalized with contrast labels using the corresponding N-hydroxysuccinimide esters. When used to detect lymph nodes, the polymers showed better imaging properties than a commercially available contrast agent.

Graphical abstract: Mannan-based conjugates as a multimodal imaging platform for lymph nodes

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Publication details

The article was received on 06 Nov 2017, accepted on 03 Jan 2018 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02888A
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Mannan-based conjugates as a multimodal imaging platform for lymph nodes

    M. Rabyk, A. Galisova, M. Jiratova, V. Patsula, L. Srbova, L. Loukotova, J. Parnica, D. Jirak, P. Stepanek and M. Hruby, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02888A

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