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Layer-by-layer fabrication of fluorescent microspheres using micelles as the spacer: simultaneously realizing fluorescence enhancement and introduction of bioconjugation sites

Abstract

The combination of fluorescent properties and other functions can significantly enhance the multipurpose appliations in functional materials. Fluorescent microspheres with strong fluorescence and bioconjugation sites were prepared by layer-by-layer introduction of poly(phenylenevinylenevinylene) (PPV) with micelles as the spacer onto the substrate spheres. First, diblock copolymer poly(acrylic acid)-block-polystyrene (PAA-b-PS) was synthesized and assembled into micelles (PSAm) with carboxylic groups outward. Then, negatively charged PSAm and positively charged PPV polymer precursor (pre-PPV) were alternately introduced onto the substrate polystyrene-divinylbenzene microspheres with sulfonic groups on the surface (SPSDVB) followed by thermal elimination to give fluorescent SPSDVB-(PPV/PSAm)n microsopheres by converting pre-PPV into PPV. The spheres were found to have stable and bright fluorescence with a very clear core-shell structure. The mechanism for fluorescence enhancement with PSAm as the spacer was studied and the capability for bioconjugation was also demonstrated. This study provides a promosing general strategy for preparing fluorescent microspheres combining strong emission with different functional groups to meet various applications.

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Publication details

The article was received on 06 Nov 2017, accepted on 03 Jan 2018 and first published on 04 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02881D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Layer-by-layer fabrication of fluorescent microspheres using micelles as the spacer: simultaneously realizing fluorescence enhancement and introduction of bioconjugation sites

    L. Sun, T. Qiu, J. Liu, K. Miao, Y. Zhao and L. Fan, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02881D

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