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Issue 3, 2018
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3D printing of pearl/CaSO4 composite scaffolds for bone regeneration

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Abstract

The development of biomaterials with high osteogenic ability for fast osteointegration with a host bone is of great interest. In this study, pearl/CaSO4 composite scaffolds were fabricated using three-dimensional (3D) printing, followed by a hydration process. The pearl/CaSO4 scaffolds showed uniform interconnected macropores (∼400 μm), high porosity (∼60%), and enhanced compressive strength. With CaSO4 scaffolds as a control, the biological properties of the pearl/CaSO4 scaffolds were evaluated in vitro and in vivo. The results showed that the pearl/CaSO4 scaffolds possessed a good apatite-forming ability and stimulated the proliferation and differentiation of rat bone mesenchymal stem cells (rBMSCs), as well as giving a better expression of related osteogenic genes. Importantly, micro-computed tomography and histology of the critical-sized rabbit femoral condyle defects implanted with the scaffolds illustrated the osteogenic capacity of the pearl/CaSO4 scaffolds. New bone was observed within 8 weeks. The bone-implant contact index was significantly higher for the pearl/CaSO4 scaffolds implant than for the CaSO4 scaffolds implant, indicating that the pearl/CaSO4 scaffolds would be promising implants for bone regeneration.

Graphical abstract: 3D printing of pearl/CaSO4 composite scaffolds for bone regeneration

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Publication details

The article was received on 07 Oct 2017, accepted on 13 Dec 2017 and first published on 14 Dec 2017


Article type: Paper
DOI: 10.1039/C7TB02667F
Citation: J. Mater. Chem. B, 2018,6, 499-509
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    3D printing of pearl/CaSO4 composite scaffolds for bone regeneration

    X. Du, B. Yu, P. Pei, H. Ding, B. Yu and Y. Zhu, J. Mater. Chem. B, 2018, 6, 499
    DOI: 10.1039/C7TB02667F

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