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A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy

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Abstract

Two-photon excited photodynamic therapy (TP-PDT) is not only able to offer deeper penetration depth but also much more precise 3D treatment than traditional one-photon excited PDT. However, the achievement of TP-PDT requires photosensitizers with large two-photon absorption cross sections, efficient generation of reactive oxygen species, and bright two-photon fluorescence. In this work, we present a simple AIE luminogen (AIEgen), IQ-TPA, with mitochondrial targeting and susceptible two-photon excitation for image-guided photodynamic therapy in cancer cells. This feasibility of utilizing small molecular multifunctional AIEgens for TP-PDT was demonstrated together with the merits of tiny size, good cell permeability, low dark cytotoxicity and easy synthesis, showing great potential for the development of future theranostic systems.

Graphical abstract: A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy

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Publication details

The article was received on 29 Sep 2017, accepted on 30 Oct 2017 and first published on 30 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02609A
Citation: J. Mater. Chem. B, 2018, Advance Article
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    A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy

    M. Jiang, R. T. K. Kwok, X. Li, C. Gui, J. W. Y. Lam, J. Qu and B. Z. Tang, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02609A

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