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Synthesis of Artificial Dental Enamel by Elastin-like Polypeptide Assisted Biomimetic Approach

Abstract

Tooth is important for our life, and enamel, as the outermost layer of the tooth, plays a key role in maintaining function and health of the tooth. The regeneration of the acid eroded enamel is a big challenge due to the lack of living cells in the enamel. Here, we proposed a novel way to chemically synthesize the enamel structure by mimicking the interaction of amorphous calcium phosphate (ACP) and acidic proteins during the natural enamel formation. The process includes the formation of ACP in situ by acid etching and then the formation of Ca-rich polypeptide-ACP complex on the acid etched enamel apatite crystals, the oriented nucleation and growth of apatite nano-crystals along the acid etched enamel apatite crystals, and infiltration of regenerated enamel apatite structure with dental resin. The synthesize enamel revealed not only excellent mechanical property, which was highly close to that of the original natural enamel, but also revealed high chemical stability against acid erosion. This innovative method implied potential applications of the functional artificial enamel for repairing the damaged tooth enamel.

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Publication details

The article was received on 26 Sep 2017, accepted on 04 Jan 2018 and first published on 04 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02576A
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Synthesis of Artificial Dental Enamel by Elastin-like Polypeptide Assisted Biomimetic Approach

    Y. Zhou, Y. Zhou, L. Gao, C. Wu and J. Chang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02576A

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