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Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

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Abstract

In this study, metalla-aromatic agents (MA) and a cluster of superparamagnetic iron oxide nanoparticles (SPIOs) were loaded inside a micellar carrier (Alkyl-PEI2k-PEG), resulting in MA/SPIOs@Alkyl-PEI2k-PEG nanoparticles (MASAs). The prepared MASAs with a photothermal transduction efficiency of 26.6% were also demonstrated as a potential photodynamic sensitizer to generate ROS effectively. Under the guidance of MRI/photoacoustic imaging, combined photothermal and photodynamic therapy achieved a synergistic anti-tumor effect, significantly improving the therapeutic efficacy of MASAs both in vitro and in vivo. This work shows that the developed MASAs are a potential theranostic agent for dual-modal imaging-guided cancer phototherapy.

Graphical abstract: Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

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Publication details

The article was received on 10 Aug 2017, accepted on 26 Sep 2017 and first published on 26 Sep 2017


Article type: Communication
DOI: 10.1039/C7TB02145C
Citation: J. Mater. Chem. B, 2018, Advance Article
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    Metalla-aromatic loaded magnetic nanoparticles for MRI/photoacoustic imaging-guided cancer phototherapy

    C. Yang, G. Lin, C. Zhu, X. Pang, Y. Zhang, X. Wang, X. Li, B. Wang, H. Xia and G. Liu, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02145C

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