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On-Demand One-Step Synthesis of Small-Sized Fluorescent-Magnetic-Bifunctional Microparticles on a Droplet-Splitting Chip

Abstract

A facile and controllable method for one-step synthesis of small-sized monodisperse fluorescent-magnetic-bifunctional microparticles was established based on droplet splitting and photopolymerization. Using this method, magnetic nanoparticles and acryloyl rhodamine B (acryloyl-RhB) molecules were incorporated into the disperse phase, which allowed the direct generation of functional microparticles. Functional microparticles with diameters in the range of 2.8 to 19.2 μm were obtained by controlling the fluidic characteristics. The fluorescence intensity of microparticles could be regulated by adjusting the concentration of acryloyl-RhB molecule in the disperse phase. Furthermore, the fluorescent-magnetic-bifunctional microparticles were successfully used to detect protein specifically by ratiometric fluorescence analysis, showing their potential in biological sample detection.

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Publication details

The article was received on 08 Aug 2017, accepted on 09 Jan 2018 and first published on 09 Jan 2018


Article type: Paper
DOI: 10.1039/C7TB02122D
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    On-Demand One-Step Synthesis of Small-Sized Fluorescent-Magnetic-Bifunctional Microparticles on a Droplet-Splitting Chip

    Y. Yang, B. Tang, L. Zhang, C. Wang, H. Ma, D. Pang and Z. Zhang, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C7TB02122D

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