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Photothermal triggered disassembly of a visible dual fluorescent poly(ethylene glycol)/α-cyclodextrin hydrogel

Abstract

Real-time tracking and adjusting of the disassembly and status of the hydrogel in vivo are important challenges for accurate and precise assessment. In this article, a photothermal controllable and visible dual fluorescent thermosensitive hydrogel was designed and developed based on a porphyrin-poly(ethylene glycol)/ IR-820-α-cyclodextrin hydrogel. Due to the photothermal effect and fluorescence emission of IR-820, it can exert the dual functions of photothermal control and fluorescence imaging tracking. IR-820 conjugated hydrogel can regulate the hydrogel disassembly by the photothermal effect of IR-820. Furthermore, each component of the hydrogel can be tracked by the fluorescence of IR-820 and porphyrin. Fluorescence imaging tracking and photothermal remote control were merged into the visible and controlled hydrogel disassembly after subcutaneous injection using mice as models. The results demonstrated that the dual fluorescence imaging visualization of cyclodextrin/poly (ethylene glycol) hydrogels revealed the disassembly process by tracking each component, and the hydrogel disassembly can accelerate efficiently under laser irradiation with the photothermal effect of IR-820. They afforded an important basis for understanding the disassembly process of the poly(ethylene glycol)/ α-cyclodextrin hydrogel.

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Publication details

The article was received on 26 Mar 2018, accepted on 11 May 2018 and first published on 17 May 2018


Article type: Paper
DOI: 10.1039/C8SM00626A
Citation: Soft Matter, 2018, Accepted Manuscript
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    Photothermal triggered disassembly of a visible dual fluorescent poly(ethylene glycol)/α-cyclodextrin hydrogel

    A. Yang, X. Dong, J. Liang, Y. Zhang, W. Yang, T. Liu, J. Yang, D. Kong and F. Lv, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM00626A

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