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Facilitated polymer capture by charge inverted electroosmotic flow in voltage-driven polymer translocation

Abstract

The optimal functioning of nanopore-based biosensing tools necessitates rapid polymer capture from the ion reservoir. We identify an ionic correlation-induced transport mechanism that provides this condition without the chemical modification of the polymer or the pore surface. In the typical experimental configuration where a negatively charged silicon-based pore confines a 1:1 electrolyte solution, anionic polymer capture is limited by electrostatic polymer-membrane repulsion and the electroosmotic (EO) flow. Added multivalent cations suppress the electrostatic barrier and revers the pore charge, inverting the direction of the EO flow that drags the polymer to the trans side. This inverted EO flow can be used to speed up polymer capture from the reservoir and to transport weakly or non-uniformly charged polymers that cannot be controlled by electrophoresis.

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Publication details

The article was accepted on 12 Apr 2018 and first published on 12 Apr 2018


Article type: Paper
DOI: 10.1039/C8SM00620B
Citation: Soft Matter, 2018, Accepted Manuscript
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    Facilitated polymer capture by charge inverted electroosmotic flow in voltage-driven polymer translocation

    S. Buyukdagli, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM00620B

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