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Issue 26, 2018
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Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM–DMA) valve for controlled loading and release of biologically active molecules

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Abstract

Mesoporous magnetic silica particles bearing a stimuli-responsive polymer valve were prepared and their performance as a microcapsule was evaluated. In this study, first, mesoporous magnetic iron oxide (Fe3O4) particles were prepared by a solvothermal method. Then, the magnetic particles were coated with silica and functionalized with vinyl groups using 3-(trimethoxysilyl)-propyl methacrylate (MPS). Subsequently, the Fe3O4/SiO2 composite particles grafted with MPS were used to carry out the seeded precipitation copolymerization of N-isopropylacrylamide (NIPAM) and 2,2-dimethylaminoethyl methacrylate (DMA). Here N,N′-methylenebisacrylamide (MBA) was used as a cross-linker. Brunauer–Emmett–Teller (BET) surface analysis suggested that the mesoporous structure was retained in the final Fe3O4/SiO2/P(NIPAM–DMA–MBA) composite hydrogel particles. The prepared Fe3O4/SiO2/P(NIPAM–DMA–MBA) composite hydrogel microspheres exhibited a pH-dependent volume phase transition. At lower pH values (<7), the inclusion of DMA shifted the volume phase transition to higher temperature because of the protonation of the tertiary amine groups. The composite hydrogel particles possessed a high saturation magnetization (51 emu g−1) and moved under the influence of an external magnetic field. The loading-release behaviour of these biologically active molecules suggested that a portion of the encapsulated guest molecules was released at a temperature below the lower critical solution temperature, LCST (<35 °C).

Graphical abstract: Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM–DMA) valve for controlled loading and release of biologically active molecules

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Publication details

The article was received on 18 Mar 2018, accepted on 06 Jun 2018 and first published on 08 Jun 2018


Article type: Paper
DOI: 10.1039/C8SM00560E
Citation: Soft Matter, 2018,14, 5469-5479
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    Mesoporous magnetic silica particles modified with stimuli-responsive P(NIPAM–DMA) valve for controlled loading and release of biologically active molecules

    M. Tanjim, M. A. Rahman, M. M. Rahman, H. Minami, S. M. Hoque, M. K. Sharafat, M. A. Gafur and H. Ahmad, Soft Matter, 2018, 14, 5469
    DOI: 10.1039/C8SM00560E

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