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Issue 15, 2018
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On the structural stability of guanosine-based supramolecular hydrogels

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Abstract

Supramolecular hydrogels formed from the self-assembly of low molecular weight derivatives are very attractive systems, because of their potential applications in nano- and bio-technology. In this paper, the stable and transparent hydrogels observed in binary mixtures of guanosine derivatives (G), namely guanosine 5′-monophosphate (GMP) and guanosine (Gua), dissolved in water (at volume fractions larger than 0.95), were investigated by microscopy techniques and Small Angle X-ray Scattering (SAXS). The results confirm the presence of G-quadruplexes, chiral cylindrical rods obtained by the regular stacking of self-assembled planar cyclic guanosine quartets. However, the addition of Gua determines the formation of very stable hydrogels able to trap large amounts of water (up to a volume fraction of 0.99) and characterised by an unusual anisotropic order. A modified lateral helix-to-helix interaction pattern, tuned by Gua, is suggested to be responsible for the supramolecular gelation and the stability of the hydrogels during swelling.

Graphical abstract: On the structural stability of guanosine-based supramolecular hydrogels

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Publication details

The article was received on 10 Feb 2018, accepted on 13 Mar 2018 and first published on 14 Mar 2018


Article type: Paper
DOI: 10.1039/C8SM00299A
Citation: Soft Matter, 2018,14, 2938-2948
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    On the structural stability of guanosine-based supramolecular hydrogels

    F. Carducci, J. S. Yoneda, R. Itri and P. Mariani, Soft Matter, 2018, 14, 2938
    DOI: 10.1039/C8SM00299A

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