Jump to main content
Jump to site search

On the structural stability of guanosine-based supramolecular hydrogels


Supramolecular hydrogels formed from the self-assembly of low molecular weight derivatives are very attractive systems, because of their potential applications in nano- and bio-technology. In this paper, the stable and transparent hydrogels observed in binary mixtures of guanosine derivatives (G), namely guanosine 5’-monophosphate (GMP) and guanosine (Gua), dissolved in water (at volume fractions larger than 0.95), were investigated by microscopy techniques and Small Angle X-ray Scattering (SAXS). Results confirm the presence of G-quadruplexes, chiral cylindrical rods obtained by the regular stacking of self-assembled planar cyclic guanosine quartets. However, the addition of Gua determines the formation of very stable hydrogels able to trap large amount of water (up to a volume fraction of 0.99) and characterised by an unusual anisotropic order. A modified lateral helix-to-helix interaction pattern, tuned by Gua, is suggested to be responsible for the supramolecular gelation and for the stability of the hydrogels during swelling.

Back to tab navigation

Publication details

The article was received on 10 Feb 2018, accepted on 13 Mar 2018 and first published on 14 Mar 2018

Article type: Paper
DOI: 10.1039/C8SM00299A
Citation: Soft Matter, 2018, Accepted Manuscript
  •   Request permissions

    On the structural stability of guanosine-based supramolecular hydrogels

    F. Carducci, J. S. Yoneda, R. Itri and P. Mariani, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM00299A

Search articles by author