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Tuning the mechanical properties of alginate-peptide Hydrogels

Abstract

Alginate, a polysaccharide that gels in the presence of divalent ions has been used in the fields of regenerative medicine to facilitate cell growth in impaired tissues by providing an artificial bio-surrounding similar to the natural Extra Cellular Matrix (ECM). Here, we present a systematic investigation of the effect of three arginine-glycine-aspartic acid (RGD) -containing peptides, G6KRGDY, A6KRGDY and V6KRGDY, on the physical properties of alginate-peptide hydrogels. Rheology measurements showed that the storage modulus of Alginate-A6KRGDY and Alginate-V6KRGDY gels is an order of magnitude higher than that of Alginate-G6KRGDY gels. Small angle X-ray Scattering (SAXS) measurements suggest that the difference in the mechanical properties of the gels is due to the formation of larger peptide junction zones additional to the ones formed by the calcium ions. These findings indicate that peptides' ability to self-assemble in aqueous solution is a significant factor in tuning the stiffness of the alginate/peptide hybrid hydrogels.

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Publication details

The article was received on 08 Jan 2018, accepted on 26 Apr 2018 and first published on 11 May 2018


Article type: Paper
DOI: 10.1039/C8SM00059J
Citation: Soft Matter, 2018, Accepted Manuscript
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    Tuning the mechanical properties of alginate-peptide Hydrogels

    G. Ochbaum, M. Davidovich-Pinhas and R. Bitton, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C8SM00059J

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