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Injectable supramolecular hydrogel hybridized with silver nanoparticles for antibacterial application

Abstract

Silver nanoparticles (AgNPs) showed long-lasting and broad-spectrum antibacterial activity. Herein, PEGylated AgNPs were prepared in-situ by complexing AgNO3 with random copolymer of poly(ethylene glycol) methyl ether methacrylate (PEGMA) and polyacrylic acid via electrostatic interaction followed by in situ reduction. AgNPs hybrid supramolecular hydrogels were thus prepared through the host-guest inclusion between PEGMA side chains and -cyclodextrins in aqueous solution. The hydrogels were physically cross-linked by both pseudopolyrotaxanes crystallization and AgNPs, which showed temperature responsiveness and self-healing properties. By hybridizing AgNPs, the hydrogels showed excellent antibacterial properties against S. aureus and E. coli bacteria while low cytotoxicity, and have potential applications as injectable antibacterial materials.

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Publication details

The article was received on 16 Nov 2017, accepted on 03 Jan 2018 and first published on 04 Jan 2018


Article type: Paper
DOI: 10.1039/C7SM02251D
Citation: Soft Matter, 2018, Accepted Manuscript
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    Injectable supramolecular hydrogel hybridized with silver nanoparticles for antibacterial application

    Y. Niu, T. Guo, X. Yuan, Y. Zhao and L. Ren, Soft Matter, 2018, Accepted Manuscript , DOI: 10.1039/C7SM02251D

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