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Issue 16, 2018
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Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

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Abstract

We investigated the effects of lipid geometry on vesicle division using coarse grained molecular dynamics simulations. When the vesicle is composed of zero and negative spontaneous curvature lipids (ZSLs and NSLs), the difference in their molecular spontaneous curvatures destabilizes the neck of the limiting shape vesicle. In the vesicle division pathway, the neck developed into the stalk intermediates. The stalk was broken when the NSLs were expelled from the stalk. Free energy analysis shows that the coupling between the lipid geometry and the Gaussian rigidity is responsible for the observed vesicle division.

Graphical abstract: Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

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Publication details

The article was received on 07 Nov 2017, accepted on 16 Feb 2018 and first published on 19 Feb 2018


Article type: Paper
DOI: 10.1039/C7SM02188G
Citation: Soft Matter, 2018,14, 3018-3027
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    Molecular mechanism of vesicle division induced by coupling between lipid geometry and membrane curvatures

    N. Urakami, T. Jimbo, Y. Sakuma and M. Imai, Soft Matter, 2018, 14, 3018
    DOI: 10.1039/C7SM02188G

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