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Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels

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Abstract

Novel biodegradable diselenide cross-linked starch-based hydrogels were synthesized via free radical copolymerization, which serve as stimuli-responsive drug release materials composed of starch chain backbones with an enzyme hydrolysis property and selenium-containing cross-linkers with a redox responsive cleavage property. Rhodamine B (RB) loaded starch-based hydrogels were prepared in order to investigate their stimuli-responsive release behaviours. In the presence of external redox agents, the enzyme stimuli as well as the mixture of the above stimuli, the prepared starch-based hydrogels exhibit controlled multi-responsive release behavior of RB. Overall, the merits of good biodegradation and multi-stimuli responsiveness make these kinds of starch-based hydrogels promising biomedical candidates for the realization of controlled drug delivery.

Graphical abstract: Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels

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Publication details

The article was received on 30 Oct 2017, accepted on 20 Dec 2017 and first published on 20 Dec 2017


Article type: Paper
DOI: 10.1039/C7SM02137B
Citation: Soft Matter, 2018, Advance Article
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    Multiple stimuli-responsive selenium-functionalized biodegradable starch-based hydrogels

    T. Sun, C. Zhu and J. Xu, Soft Matter, 2018, Advance Article , DOI: 10.1039/C7SM02137B

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