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A modular approach for multifunctional polymersomes with controlled adhesive properties

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Abstract

The bottom-up approach in synthetic biology involves the engineering of synthetic cells by designing biological and chemical building blocks, which can be combined in order to mimic cellular functions. The first step for mimicking a living cell is the design of an appropriate compartment featuring a multifunctional membrane. This is of particular interest since it allows for the selective attachment of different groups or molecules to the membrane. In this context, we report on a modular approach for polymeric vesicles, so-called polymersomes, with a multifunctional surface, namely hydroxyl, alkyne and acrylate groups. We demonstrate that the surface of the polymersome can be functionalized to facilitate imaging, via fluorescent dyes, or to improve the specific adhesion to surfaces by using a biotin functionalization. This generally applicable multifunctionality allows for the covalent integration of various molecules in the membrane of a synthetic cell.

Graphical abstract: A modular approach for multifunctional polymersomes with controlled adhesive properties

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Publication details

The article was received on 19 Sep 2017, accepted on 15 Dec 2017 and first published on 15 Dec 2017


Article type: Paper
DOI: 10.1039/C7SM01885A
Citation: Soft Matter, 2018, Advance Article
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    A modular approach for multifunctional polymersomes with controlled adhesive properties

    J. Petit, L. Thomi, J. Schultze, M. Makowski, I. Negwer, K. Koynov, S. Herminghaus, F. R. Wurm, O. Bäumchen and K. Landfester, Soft Matter, 2018, Advance Article , DOI: 10.1039/C7SM01885A

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