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Issue 16, 2018
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Pd(II)-catalyzed synthesis of bifunctionalized carboranes via cage B–H activation of 1-CH2NH2-o-carboranes

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Abstract

Aminoalkyl carboranes are anticipated to be valuable synthons toward the synthesis of bifunctionalized carboranes. However, direct cage boron derivation of these carborane derivatives has not been solved. Herein, the reversible conversion of catalytically infeasible o-carboranyl methylamines (1-CH2NH2-o-carboranes) into bidentate imines initiates Pd-mediated cage B–H activation. As a result, an amine coordinated bicyclic Pd(II) complex (3) has been isolated and proven to be the catalytically active intermediate for highly site-selective B–H diarylation of o-carboranyl methylamines. Using glyoxylic acid as an inexpensive and commercially available transient directing reagent, a wide range of cage B(4,5)-diarylated free primary o-carboranyl methylamines were prepared in good to excellent yields with the avoidance of the pre-installation and removal of a directing group. This method provides easy access to cage boron functionalized o-carboranyl methylamines with potential for application in pharmaceuticals.

Graphical abstract: Pd(ii)-catalyzed synthesis of bifunctionalized carboranes via cage B–H activation of 1-CH2NH2-o-carboranes

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Publication details

The article was received on 12 Mar 2018, accepted on 26 Mar 2018 and first published on 27 Mar 2018


Article type: Edge Article
DOI: 10.1039/C8SC01154K
Citation: Chem. Sci., 2018,9, 3964-3969
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    Pd(II)-catalyzed synthesis of bifunctionalized carboranes via cage B–H activation of 1-CH2NH2-o-carboranes

    X. Zhang and H. Yan, Chem. Sci., 2018, 9, 3964
    DOI: 10.1039/C8SC01154K

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