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Issue 26, 2018
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Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells

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Abstract

Reversibly controlled generation of singlet oxygen from photosensitizing nanosystems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We report a strategy for integrating photochromic spiropyrans into biocompatible cationic polymers, which involved assembling nucleic acids into functional nanoparticles without introducing additional photosensitizers and imaging agents. We found that spiropyran-containing nanoparticles have photoswitching properties for both fluorescence (with a quantum yield of up to 0.27) and singlet oxygen generation (with a quantum yield of up to 0.22) in aqueous solutions and cells, and demonstrated that spiropyrans in nanoassemblies featuring aggregation-induced enhanced photosensitization and emission could be potentially applied in photodynamic therapy studies on tumor cells.

Graphical abstract: Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells

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Publication details

The article was received on 12 Mar 2018, accepted on 11 Jun 2018 and first published on 11 Jun 2018


Article type: Edge Article
DOI: 10.1039/C8SC01148F
Citation: Chem. Sci., 2018,9, 5816-5821
  • Open access: Creative Commons BY-NC license
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    Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells

    J. Ji, X. Li, T. Wu and F. Feng, Chem. Sci., 2018, 9, 5816
    DOI: 10.1039/C8SC01148F

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