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Issue 20, 2018
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Self-reporting and refoldable profluorescent single-chain nanoparticles

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Abstract

We pioneer the formation of self-reporting and refoldable profluorescent single-chain nanoparticles (SCNPs) via the light-induced reaction (λmax = 320 nm) of nitroxide radicals with a photo-active crosslinker. Whereas the tethered nitroxide moiety in these polymers fully quenches the luminescence (i.e. fluorescence) of the aromatic backbone, nitroxide trapping of a transient C-radical leads to the corresponding closed shell alkoxyamine thereby restoring luminescence of the folded SCNP. Hence, the polymer in the folded state is capable of emitting light, while in the non-folded state the luminescence is silenced. Under oxidative conditions the initially folded SCNPs unfold, resulting in luminescence switch-off and the reestablishment of the initial precursor polymer. Critically, we show that the luminescence can be repeatedly silenced and reactivated. Importantly, the self-reporting character of the SCNPs was followed by size-exclusion chromatography (SEC), dynamic light scattering (DLS), fluorescence, electron paramagnetic resonance (EPR), nuclear magnetic resonance (NMR) and diffusion ordered NMR spectroscopy (DOSY).

Graphical abstract: Self-reporting and refoldable profluorescent single-chain nanoparticles

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Publication details

The article was received on 02 Mar 2018, accepted on 29 Apr 2018 and first published on 30 Apr 2018


Article type: Edge Article
DOI: 10.1039/C8SC01009A
Citation: Chem. Sci., 2018,9, 4696-4702
  • Open access: Creative Commons BY-NC license
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    Self-reporting and refoldable profluorescent single-chain nanoparticles

    T. S. Fischer, S. Spann, Q. An, B. Luy, M. Tsotsalas, J. P. Blinco, H. Mutlu and C. Barner-Kowollik, Chem. Sci., 2018, 9, 4696
    DOI: 10.1039/C8SC01009A

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