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Issue 19, 2018
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Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

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Abstract

Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as complementary tools to visualize and analyze biological systems. Among them, X-ray fluorescence microspectroscopy provides information on the local content and distribution of heavy elements (Z ≥ 14) in cells or biological samples. In this context, similar tools to those developed for fluorescence microscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-ray fluorescence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.

Graphical abstract: Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

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Publication details

The article was received on 23 Feb 2018, accepted on 13 Apr 2018 and first published on 13 Apr 2018


Article type: Edge Article
DOI: 10.1039/C8SC00886H
Citation: Chem. Sci., 2018,9, 4483-4487
  • Open access: Creative Commons BY license
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    Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

    S. Hostachy, M. Masuda, T. Miki, I. Hamachi, S. Sagan, O. Lequin, K. Medjoubi, A. Somogyi, N. Delsuc and C. Policar, Chem. Sci., 2018, 9, 4483
    DOI: 10.1039/C8SC00886H

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