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Rational Designed Upconversion Nanoprobe for Simultaneously High Sensitive Fluoride Ions Ratiometric Detection and Fluorosis Theranostic

Abstract

Fluorosis has been considered as a worldwide disease for many of years, which seriously diminished life quality through skeletal embrittlement and hepatic damage. Aim to develop novel drugs for simultaneous fluorosis diagnosis and therapy, we explored the feasibility of a novel pyrogallic acid-titanium (IV) complex-modified upconversion nanoprobe (UCNP-PA-Ti) for F- capture and real-time quantification in this work. Utilizing strong interaction between Ti4+ and F-, the modified PA-Ti would decompose in F--contained solution, which not only weakened the FRET but resulted in upconversion luminescence (UCL) recovery. Both in vitro and in vivo experiment demonstrated the high sensitive F- UCL response and therapeutic efficiency, which promised the successful UCL imaging monitored and the therapeutic process. The long blood circulation time and low toxicity ensured their safety for fluorosis theranostics application. Our work provide a new possibility toward the F- concentration detection within fluorosis therapeutic period and encouraged the development of novel drugs for fluorosis theranostics as well.

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Publication details

The article was received on 09 Feb 2018, accepted on 03 May 2018 and first published on 09 May 2018


Article type: Edge Article
DOI: 10.1039/C8SC00670A
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Rational Designed Upconversion Nanoprobe for Simultaneously High Sensitive Fluoride Ions Ratiometric Detection and Fluorosis Theranostic

    Y. Liu, A. Jiang, Q. Jia, X. Zhai, L. Liu, L. Ma and J. Zhou, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8SC00670A

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