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Issue 11, 2018
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Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl2 as a stoichiometric formylating reagent

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Abstract

The first example of copper-catalyzed direct formylation of alkenyl C–H bonds for the facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and a broad substrate scope. BrCHCl2 is expected to be developed as an efficient stoichiometric C1 building block in organic synthesis.

Graphical abstract: Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl2 as a stoichiometric formylating reagent

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Publication details

The article was received on 14 Jan 2018, accepted on 13 Feb 2018 and first published on 14 Feb 2018


Article type: Edge Article
DOI: 10.1039/C8SC00210J
Citation: Chem. Sci., 2018,9, 2986-2990
  • Open access: Creative Commons BY license
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    Copper-catalyzed formylation of alkenyl C–H bonds using BrCHCl2 as a stoichiometric formylating reagent

    Y. Bao, G. Wang, Y. Zhang, K. Bian and X. Wang, Chem. Sci., 2018, 9, 2986
    DOI: 10.1039/C8SC00210J

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