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Copper-catalyzed formylation of alkenyl C-H bonds with BrCHCl2 used as a stoichiometric formylating reagent

Abstract

The first example of copper-catalyzed direct formylation of alkenyl C-H bonds for facile synthesis of α,β-unsaturated aldehydes has been developed. This transformation has demonstrated high reactivity, mild reaction conditions and broad substrate scope. BrCHCl2 is expected to be developed as an effcient stoichimetric C1 bulding block in organic synthesis.

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Publication details

The article was received on 14 Jan 2018, accepted on 13 Feb 2018 and first published on 14 Feb 2018


Article type: Edge Article
DOI: 10.1039/C8SC00210J
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Copper-catalyzed formylation of alkenyl C-H bonds with BrCHCl2 used as a stoichiometric formylating reagent

    X. Wang, Y. Bao, G. Wang, Y. Zhang and K. Bian, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8SC00210J

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