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Nanobubble-Embedded Inorganic 808 nm excited-Upconversion Nanocomposites for Tumorous Multiple Imaging and Treatment

Abstract

Contrast reagents for ultrasound imaging are widely used in clinical medical diagnosis because ultrasound resolution is limited. Contrast agents must be utilized to enhance the image resolution. At present, microbubbles (MBs) and nanobubbles (NBs) are the candidates of contrast reagents to improve the signal resolution. Upconverted fluorescence provides high sensitivity and also functions as a nanocarrier. It can label tumor cells in a specific organ under the irradiation of near-infrared (NIR) light. However, despite the use of NIR light, the penetration depth of NIR is only approximately 15 mm. Thus, we combine fluorescence with ultrasonic imaging to achieve the effect of multiple imaging and solve the lack of fluorescent penetration depth and the poor resolution of ultrasound imaging. The dual imaging modalities achieved higher resolution or signal to noise ratios. In this study, Nd3+-sensitized upconversion nanoparticles (UCNPs) are combined with graphitic carbon nitride quantum dots (CNs) and embedded in NBs (UCNP–CN@NBs). The UCNPs are excited by the 808 nm light and emitted visible and ultraviolet light. Then, the energy of the ultraviolet light is transferred to the CNs to produce reactive oxygen species for photodynamic therapy. Ultrasonic waves are also used to promote the bubble burst and release reactive oxygen species molecules by applying photodynamic therapy, leading to cancer cell apoptosis.

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Publication details

The article was received on 09 Jan 2018, accepted on 01 Feb 2018 and first published on 09 Feb 2018


Article type: Edge Article
DOI: 10.1039/C8SC00108A
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Nanobubble-Embedded Inorganic 808 nm excited-Upconversion Nanocomposites for Tumorous Multiple Imaging and Treatment

    M. Chan, Y. Pan, Y. Chan, M. Hsiao, C. Chen, L. Sun and R. Liu, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C8SC00108A

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