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Bioresponsiveness and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules

Abstract

Developing nanotheranostic with responsiveness to tumor microenvironment has attracted tremendous attention for on-demand cancer diagnosis and treatment. Herein, a facile Mn-doping strategy was adopted to transform the mesoporous silica coated upconversion nanoparticles (UCNPs) to yolk-like upconversion nanostructure which poses tumor-responsive biodegradation nature. The huge internal space of the innovated nanocarriers is suitable for doxorubicin (DOX) storage, besides the Mn-doped shell is sensitive to the intratumoral acidity and reducibility, which enables the shell biodegradation and further accelerates the breakage of Si–O–Si bonds within the silica framework. This tumor-responsive shell degradation is beneficial for realizing tumor-specific DOX release. Subsequently, polyoxometalate (POM) nanocluster that can enhance photothermal conversion in response to the tumor reducibility and acidity was modified on the surface of the silica shell, thereby achieving NIR-enhanced shell degradation and also preventing the premature DOX leakage. The as-produced thermal effect of POM couples with the chemotherapy effect of the released DOX to perform a synergetic chemo-photothemal therapy. Additionally, the shell degradation brings size shrinkage to the nanocarriers, allowing faster nanoparticle diffusion and deeper tumor penetration, which is significant for improving theranostic outcome. Also, the drastic decline of the red/green (R/G) ratio caused by DOX release can be used to monitor the DOX release content through a fluorescence resonance energy transfer (FRET) way. The MRI effect caused by Mn release together with the MRI/CT/UCL imaging derived from Gd3+/Yb3+/Nd3+/Er3+ co-doped UCNPs under 808 nm laser excitation endow the nanosystem multiple imaging capability, thus realizing imaging-guided cancer therapy.

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Publication details

The article was received on 21 Dec 2017, accepted on 31 Jan 2018 and first published on 06 Feb 2018


Article type: Edge Article
DOI: 10.1039/C7SC05414A
Citation: Chem. Sci., 2018, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Bioresponsiveness and near infrared photon co-enhanced cancer theranostic based on upconversion nanocapsules

    J. Xu, W. Han, Z. Cheng, P. Yang, H. Bi, D. Yang, N. Niu, F. He, S. Gai and J. Lin, Chem. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7SC05414A

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